C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) C07C 253/30 (2006.01) C07C 255/58 (2006.01) C07C 321/24 (2006.01) C07D 221/08 (2006.01) C07D 239/86 (2006.01) C07D 265/30 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2431679
This invention relates to a method for the regioselective synthesis of 4,6,7,8- substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti- cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
L'invention concerne un procédé de synthèse régiosélective de 4,6,7,8 benzo[g]quinoline-3-carbonitriles et de 4,6,7,8 benzo[g]quinazolines substitués ainsi que des intermédiaires de ceux-ci. Les composés dérivés de l'invention sont utilisés pour traiter une variété de maladies induites par la dérégulation des PTK et plus particulièrement comme agents anticancéreux, et pour traiter le cancer chez les mammifères. L'invention concerne également des composés dérivés utilisés pour traiter une maladie polykystique en insuffisance rénale chez les mammifères.
Berger Dan Maarten
Birnberg Gary Harold
Wang Yanong
Ridout & Maybee Llp
Wyeth
LandOfFree
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