Method for the removal of the formyl group from an ester of...

Details Method for the removal of the formyl group from an ester of... Method for the removal of the formyl group from an ester of...

C - Chemistry, Metallurgy

07

K

530/5.06, 260/47

C07K 1/06 (2006.01) C07K 1/12 (2006.01) C07K 5/06 (2006.01) C07K 5/075 (2006.01)

Patent

CA 1290896

METHOD FOR THE REMOVAL OF THE FORMYL GROUP FROM AN ESTER OF AN N-FORMYL PEPTIDE OR N-FORMYL AMINOACID ABSTRACT OF THE DISCLOSURE A method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid, in which the ester is reacted with urea in the presence of a polar solvent and a strong acid, is disclosed. The method is highly selective and gives a high reaction yield, and can be carried out with the use of reagents which are widely available on the market and of low cost.

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