Method for the resolution of folinic acid

Details Method for the resolution of folinic acid Method for the resolution of folinic acid

C - Chemistry, Metallurgy

07

D

260/242.13

C07D 475/04 (2006.01)

Patent

CA 2002430

A process is provided for separating diastereomers of (6R,S)-folinates. The process includes adding a sufficient amount of a water-soluble alkali metal salt of an inorganic acid or of an organic acid or a water-soluble ammonium salt of an inorganic acid or of an organic acid to an aqueous starting solution of an alkali metal salt of (6R,S)-folinic acid or an alkaline earth metal salt of (6R,S)-folinic acid at a neutral pH to precipitate the (6R)-folinate. The resultant (6R)-folinate precipitate is then separated off. The (6S)-folinate is then isolated from the filtrate.

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