Method for the selection of endothelial cells death inducers...

Details Method for the selection of endothelial cells death inducers... Method for the selection of endothelial cells death inducers...

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2749049

The present invention relates to an in vitro method for selecting a compound capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels. The invention further comprises the use of netrin-1 function inhibitors as compounds capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels of tumor expressing netrin-1. Finally, the invention relates to a kit for the selection of a compound capable to induce the death of endothelial cells.

La présente invention porte sur un procédé in vitro pour la sélection d'un composé apte à induire la mort de cellules endothéliales, de préférence de cellules endothéliales provenant de vaisseaux ou de néovaisseaux. L'invention porte en outre sur l'utilisation d'inhibiteurs de la fonction de la nétrine-1 comme composés aptes à induire la mort de cellules endothéliales, de préférence de cellules endothéliales provenant de vaisseaux ou de néovaisseaux d'une tumeur exprimant la nétrine-1. Enfin, l'invention porte sur une trousse pour la sélection d'un composé apte à induire la mort de cellules endothéliales.

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