C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 253/34 (2006.01) C07C 253/30 (2006.01) C07C 255/59 (2006.01) C07D 307/87 (2006.01)
Patent
CA 2555980
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3- hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4- dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3- hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
L'invention concerne une technique de séparation et d'isolement d'un dérivé acylaté de of 4-[(S)-4-diméthylamino-1-(4-fluorophényl)-1-hydroxybutyl]-3-hydroxyméthylbenzonitrile par réaction d'un mélange de 4-[(S)-4-diméthylamino-1-(4-fluorophényl)-1-hydroxy-butyl]-3-hydroxyméthylbenzonitrile et d'un dérivé acylaté de cette substance avec un composé qui forme un dérivé de 4-[(S)-4-diméthylamino-1-(4-fluorophényl)-1-hydroxy-butyl]-3-hydroxyméthylbenzonitrile contenant un groupe acide carboxylique. Le dérivé acylaté contenant un groupe acide carboxylique précipite une fois formé et peut être séparé facilement du mélange de réaction.
Goudreau Gage Dubuc
H. Lundbeck A/s
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