C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/34 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2544153
A method for synthesising a bifunctional complex which comprises a reaction product and an encoding region. The complex is a hybridisation product between a nascent bifunctional complex and a building block. The nascent bifunctional complex comprises an attachment entity linked to an oligonucleotide identifier region and the building block comprises a fuctional entity attached to an oligonucleotide which is sufficiently complementary to the identifier region to allow for hybridisation . The functional entity may then be transferred to the attachment entity by a chemical reaction.The complementary identifier region further comprises a unique codon, which identifies the functional entity unequivocally. This codon functions as a template for forming a unique codon as an extention of the identifier region by use of an enzime, such as a polymerase. The unique codon may be used to decode the synthetic history of the reaction product after several cycles of transfer of functional entities.
La présente invention concerne un procédé permettant d'obtenir un complexe double fonction comprenant une partie molécule de présentation et une partie codage. En l'occurrence, on prend un complexe double fonction naissant comprenant, d'une part un site de réaction chimique, et d'autre part un site d'amorçage suscitant l'adjonction enzymatique d'un marqueur. On fait réagir ce complexe au niveau du site de réaction avec au moins un réactif, et on l'équipe de marqueurs identifiant les différents réactifs au niveau du site d'amorçage grâce à au moins une enzyme.
Felding Jakob
Franch Thomas
Freskgard Per-Ola
Glad Sanne Schroder
Gouliaev Alex Haahr
Nuevolution A/s
Sim & Mcburney
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