Method for the synthesis of exocyclic derivatives of...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/30 (2006.01)

Patent

CA 2550080

The invention relates to a method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines. The invention is characterised in that the method comprises a step consisting in demixing a solution containing said synthesised derivative, by reacting a heterocyclic amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. According to the invention, the starting amine which has not reacted is collected and reused directly without any additional treatment. The inventive method can also be used to obtain the corresponding exocyclic heterocycloalkyl-hydrazine or cycloalkyl-hydrazinederivative derivative at a low cost compared to that of other known methods.

La présente invention concerne un procédé de synthèse de dérivés de cycloalkyl~ hydrazines exocycliques et de dérivés d'hétérocycloalkyl- hydrazines exocycliques. Le procédé se caractérise en ce qu'il comprend une étape de démixtion la solution comprenant ledit dérivé synthétisé, par réaction d'une amine hétérocyclique avec de la monochloramine, en une phase organique et une phase aqueuse par l'ajout d'hydroxyde de sodium anhydre. L'amine de départ qui n'a pas réagi est récupérée et réutilisée directement, sans traitement supplémentaire. Le procédé de la présente invention permet ainsi l'obtention du dérivé de cycloalkyl-hydrazine ou d'hétérocycloalkyl~hydrazine exocyclique correspondant avec un coût très peu élevé par rapport aux autres procédés connus.

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