Method for the synthesis of phosphorus atom modified nucleic...

Details Method for the synthesis of phosphorus atom modified nucleic... Method for the synthesis of phosphorus atom modified nucleic...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01)

Patent

CA 2744987

Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H- phophonate moiety with a nucleoside/nucleotide.

La présente invention concerne des procédés pour la synthèse dacides nucléiques modifiés par des atomes de phosphore comportant des groupes fonctionnels X-phosphonate chiraux. Les procédés selon linvention fournissent des acides nucléiques à squelette carboné modifié présentant une pureté diastéréomérique élevée par une réaction asymétrique dune molécule achirale comprenant une groupe fonctionnel H-phosphonate chimiquement stable avec un nucléoside/nucléotide.

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