Method for the synthesis of trisodium phosphonoformate...

Details Method for the synthesis of trisodium phosphonoformate... Method for the synthesis of trisodium phosphonoformate...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01)

Patent

CA 2053270

The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50 °C, adding trie- thyl phosphonoformate to said solution at 50 °C, heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.

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