Method for the treatment of acute myeloid leukemia

Details Method for the treatment of acute myeloid leukemia Method for the treatment of acute myeloid leukemia

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2759597

The invention is in the field of molecular medicine and provides methods for the treatment of acute myeloid leukemia. These methods are based on the observation that microRNA-9 and microRNA-9* are involved in the pathogenesis of the disease in that the overexpression of microRNA-9/9* block myeloid differentiation in vitro. More in particular, microRNA-9/9* were found to play a role in leukemic transformation in acute myeloid leukemia.

Cette invention concerne le domaine de la médecine moléculaire et apporte des méthodes de traitement de la leucémie aiguë myéloblastique. Ces méthodes reposent sur l'observation selon laquelle le microARN-9 et le microARN-9* sont impliqués dans la pathogenèse de la maladie, dans la mesure où la surexpression des microARN-9/9* bloque la différenciation myéloïde in vitro. En particulier, les microARN-9/9* s'avèrent jouer un rôle dans la transformation leucémique de la leucémie aiguë myéloblastique.

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