Method for the treatment of atherosclerosis and vascular...

A - Human Necessities – 61 – K

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A61K 31/55 (2006.01)

Patent

CA 2277022

A method for the treatment of atherosclerosis and vascular injury using exochelins, and more particularly exochelins of Mycobacterium tuberculosis, to prevent vascular smooth muscle cell proliferation. Delivery of an effective amount of a desferri-Exochelins to a living organism such as an animal or a human by oral, intravenous or direct delivery to the site at which the effect is desired will protect blood vessels in a living organism from restenosis following angioplasty or vascular surgery and will prevent or slow the progression of atherosclerosis, systemic hypertension, radiation damage to the vasculature, stenosis or closure of bypass grafts to the coronary arteries or other blood vessels following a surgical procedure and various forms of pulmonary hypertension.

La présente invention concerne un procédé de traitement de l'athérosclérose et des lésions vasculaires utilisant des exochélines et plus particulièrement, des exochélines de bacille de la tuberculose, de manière à empêcher la prolifération des cellules vasculaires d'un muscle lisse. L'administration d'une quantité efficace de desferri-exochélines à un organisme vivant tel qu'un animal ou un humain par voie orale ou intraveineuse ou l'administration directe au site sur lequel on souhaite un effet, protège les vaisseaux sanguins d'un organisme vivant contre la resténose qui suit une angioplastie ou une chirurgie vasculaire et empêche ou ralentit l'évolution de l'athérosclérose, de l'hypertension systémique, des radiolésions sur le système vasculaire, de la sténose, de l'obturation des greffes de pontage coronarien ou d'autres vaisseaux sanguins après une procédure chirurgicale, et différentes formes d'hypertension pulmonaire.

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