C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 38/18 (2006.01) A61K 38/43 (2006.01) A61K 38/51 (2006.01) A61L 27/22 (2006.01)
Patent
CA 2346375
The invention relates to a method of treatment for a mammal in need of chemonucleolysis. The method comprising the administration of an effective proteoglycan cleaving amount of a proteoglycan-degrading enzyme and an effective amount of a growth factor effective in promoting the synthesis of a matrix component. The proteoglycan-degrading enzyme is preferably chondroitinase. The growth factor is preferably osteogenic protein. The proteoglycan-degrading enzyme and the growth factor are preferably administered simultaneously.
L'invention concerne un procédé de traitement pour un mammifère ayant besoin d'une chimionucléolyse. Ledit procédé consiste administrer une dose efficace de clivage de protéoglycane, d'une enzyme dégradant la protéoglycane et une dose efficace d'un facteur de croissance efficace pour favoriser la synthèse d'un composant matriciel. Ladite enzyme dégradant la protéoglycane est de préférence de la chondroitinase. Le facteur de croissance est de préférence une protéine ostéogène. L'enzyme de dégradation de protéoglycane et le facteur de croissance sont de préférence administrés simultanément.
An Howard
Masuda Koichi
Sampath Kuber T.
Thonar Eugene J-M.a.
An Howard
Gowling Lafleur Henderson Llp
Masuda Koichi
Rush-Presbyterian-St. Luke's Medical Center
Sampath Kuber T.
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