Method for the treatment of corticosteroid induced osteopenia

A - Human Necessities – 61 – K

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A61K 38/29 (2006.01) C07K 14/635 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223832

Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa)2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of corticosteroid induced osteopenia in mammals.

L'invention se rapporte à des analogues polypeptidiques synthétiques de l'hormone parathyroïde (PTH), de la protéine liée à cette hormone (PTH-rp) ainsi qu'aux homologues et aux analogues tronqués physiologiquement actifs de la PTH et de la PTH-rp, où les résidus d'acides aminés (22-31) forment une hélice alpha amphipathique. Les résidus en question (22-31) sont choisis parmi les acides aminés hydrophiles (Haa) et les acides aminés lipophiles (Laa) ordonés dans la séquence: Haa(Laa Laa Haa Haa)¿2? Laa. Les analogues décrits dans l'invention et leurs sels pharmaceutiquement acceptables sont utiles pour la prophylaxie et le traitement de costéopénie induite par les corticostéroïdes chez les mammifères.

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