Method for the treatment of diseases or disorders of the...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61P 27/16 (2006.01) C12N 15/11 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2320717

The invention relates to a method for treating diseases or disorders of the inner ear linked with damage or destruction of sensory cells of the inner ear, in which sensory cells of the inner ear are preferably regenerated by stimulating the proliferation of supporting cells, using cell cycle inhibitors such as cyclin-dependent kinase inhibitors, such as in particular the cyclin-dependent kinase inhibitor p27Kip1.

L'invention concerne un procédé pour traiter des maladies ou des troubles de l'oreille interne liés à une lésion ou à la destruction des cellules sensorielles de l'oreille interne. Au moins un principe actif est utilisé pour la régénération des cellules sensorielles, lequel inhibe ou élimine au moins partiellement l'effet inhibant d'au moins un inhibiteur de cycle cellulaire présent dans l'oreille interne, et la régénération des cellules sensorielles de l'oreille interne s'effectue de préférence par stimulation de la prolifération des cellules de soutien. Les cellules sensorielles de l'oreille interne sont les cellules épithéliales pourvues de poils. Les inhibiteurs de cycle cellulaire sont des inhibiteurs de la cycline-kinase et notamment l'inhibiteur de la cycline-kinase p27<Kip1>.

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