A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/17 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 38/17 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)
Patent
CA 2422889
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable DP IV inhibitor leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) in the brain of mammals. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1-36). As a consequence of the resulting enhanced stability of the endogenous NPY (1- 36), NPY activity is prolonged thereby resulting among other things in functionally active NPY YI receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, antihypertension and other neurological effects.
L'invention concerne un procédé pour le traitement chez un animal, y compris l'homme, de troubles psychosomatiques, dépressifs et neuropsychiatriques, comme l'anxiété, la dépression, l'insomnie, la schizophrénie, l'épilepsie, le spasme et la douleur chronique. L'administration d'un inhibiteur approprié de DP IV réduit la dégradation du neuropeptide Y (NPY). Ce traitement réduit ou retarde la baisse de la concentration de NPY (1-36) neuronal actif sur le plan fonctionnel. Il en résulte une stabilité améliorée de NPY(1-36) endogène, une prolongation de l'activité de NPY entraînant notamment une activité du récepteur Y1 de NPY actif sur le plan fonctionnel qui facilite les effets antidépresseurs, anxiolytiques, analgésiques, antihypertension et autres effets neurologiques.
Demuth Hans-Ulrich
Hoffmann Matthias
Kask Ants
Kruber Susanne
Nguyen Huu Phuc
Macrae & Co.
Probiodrug Ag
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