Method for the treatment of neurological and...

A - Human Necessities – 61 – K

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A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/17 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 38/17 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2424475

The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable attractin inhibitor causes the reduction of activity in the enzyme attraction or in isoforms thereof in the brain of mammals and leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) and similar substrates. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1-36). As a consequence of the resulting enhanced stability of the endogenous NPY(1-36), NPY activity is prolonged thereby resulting among other things in functionally active NPY Y1 receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, antihypertension and other neurological effects.

L'invention concerne un procédé pour le traitement chez un animal, y compris l'homme, de troubles psychosomatiques, dépressifs et neuropsychiatriques, comme l'anxiété, la dépression, l'insomnie, la schizophrénie, l'épilepsie, le spasme et la douleur chronique. L'administration d'un inhibiteur approprié d'attractine réduit l'activité d'attractine enzymatique ou d'isoformes correspondantes dans le cerveau et réduit donc la dégradation du neuropeptide Y (NPY) et des substrats similaires. Ce traitement réduit ou retarde la baisse de la concentration de NPY (1-36) neuronal actif sur le plan fonctionnel. Il en résulte une stabilité améliorée de NPY(1-36) endogène, une prolongation de l'activité de NPY entraînant notamment une activité du récepteur Y1 de NPY actif sur le plan fonctionnel qui facilite les effets antidépresseurs, anxiolytiques, analgésiques, antihypertension et autres effets neurologiques.

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