Method for the treatment of overactive bladder

Details Method for the treatment of overactive bladder Method for the treatment of overactive bladder

A - Human Necessities

61

K

A61K 31/506 (2006.01) A61K 31/496 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2465140

Treatment or prevention of OAB or UI in mammals, particularly humans, is disclosed using NK2R binding compounds in accord with structural diagram (I) wherein A, R1, R2, R3 and R4 are as defined in the specification. Pharmaceutically-advantageous salts of the compounds, methods of use of the compounds, either alone or in combination with other pharmacological agents, and pharmaceutical compositions useful in practicing the methods of the invention are also disclosed.

Cette invention concerne le traitement ou la prévention de la suractivité de la vessie ou de l'incontinence urinaire chez les mammifères, en particulier chez les êtres humains, utilisant des composés se liant au récepteur de la neurokinine 2 (NK2R) et représentés par la formule (I), dans laquelle A, R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans la description. Cette invention porte également sur des sels pharmaceutiquement efficaces de ces composés, sur des méthodes d'utilisation de ces composés, utilisés seuls ou associés à d'autres agents pharmacologiques et sur des compositions pharmaceutiques servant à mettre en oeuvre les méthodes de cette invention.

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