A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01) A61K 31/7036 (2006.01) A61M 11/00 (2006.01) A61M 13/00 (2006.01) A61P 11/00 (2006.01) A61P 11/08 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2355775
A method for treatment of severe chronic bronchitis (bronchiectasis) using a concentrated aminoglycoside antibiotic formulation delivering the antibiotic to the lung endobronchial space including alveoli in an aerosol or dry powder having mass medium diameter predominately between 1 to 5 microns. The method comprises administration of the antibiotic in a concentration one to ten thousand times higher than the minimal inhibitory concentration of the target organism. Preferably, the method comprises endobronchial administration of aerosol or dry powder tobramycin to treat pseudomonal infections in severe chronic bronchitis (bronchiectasis) patients.
On décrit un procédé de traitement de la bronchite chronique sévère (bronchiectasie) à l'aide d'une formulation concentrée d'aminoside qui apporte l'antibiotique dans l'espace endobronchique pulmonaire y compris les alvéoles sous forme d'aérosol ou de poudre sèche dont le diamètre particulaire moyen se situe principalement entre 1 et 5 microns. Le procédé consiste à administrer l'antibiotique suivant une concentration qui est de une à dix mille fois supérieure à la concentration inhibitrice de l'organisme cible. Le procédé comprend de préférence l'administration endobronchique de tobramycine en aérosol ou en poudre sèche pour traiter les infections pseudomonales chez des patients souffrant de bronchite chronique sévère (bronchiectasie).
Baker William R.
Montgomery Alan B.
Borden Ladner Gervais Llp
Novartis Vaccines And Diagnostics Inc.
Pathogenesis Corporation
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