C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2562764
The present invention relates generally to binding agents useful in the selective depletion of T cells in vivo. More specifically, the invention relates to ICOS-binding agents which once bound to ICOS expressed on the surface of cells, in particular ICOS-bearing activated T cells, result in the in vivo depletion of cells to which they are bound. Methods of treating T cell related diseases using said ICOS-binding agents, and pharmaceutical compositions comprising said ICOS-binding agents, a method of identifying an ICOS-binding agent, and monoclonal anti-ICOS antibodies capable of eliminating cells in vivo which express ICOS on their surface are also provided.
L'invention concerne, d'une manière générale, des agents de liaison utiles dans la déplétion sélective de lymphocytes T in vivo. Plus précisément, l'invention concerne des agents de liaison à ICOS, lesquels, une fois liés à ICOS exprimé sur la surface de cellules, notamment des lymphocytes T supportant ICOS, provoquent la déplétion in vivo des cellules auxquelles ils sont liés. L'invention concerne également des méthodes de traitement de maladies relatives aux lymphocytes T mettant en oeuvre des agents de liaison à ICOS et des compositions pharmaceutiques renfermant les agents de liaison à ICOS, un procédé d'identification d'un agent de liaison à ICOS et des anticorps monoclonaux anti-ICOS capables d'éliminer des cellules in vivo exprimant ICOS sur leur surface.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Bundesrepublik Deutschland Letztvertreten Durch Das Robert-Koch-
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