A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/04 (2006.01) A61K 31/195 (2006.01)
Patent
CA 2117199
The present invention provides a method for the treatment of the complications and pathology of diabetes. The method involves the administration to a diabetic subject of a composition comprising a compound selected from the group consisting of (.beta.-Ala-His)n, (Lys-His)n, a compound of the formula R1-X-R2, pharmaceutically acceptable salts thereof and combinations thereof; and a pharmaceutically acceptable carrier, in which n is 2-5, R1 is one or two naturally occurring amino acids, optionally alpha-amino acetylated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R2 is 1 or 2 naturally occurring amino acids, optionally alpha-carboxyl esterified or amidated with alkyl or aralkyl of 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms and X is R3-L or D-His (R4)-R5 where R3 is void or .omega.-aminoacyl with 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms, R4 is void or imidazole modification with alkyl-sulphydryl, hydroxyl, halogen and/or amino groups; and R5 is void or carbonyl (alkyl) amides with 1 to 12 carbon atoms, preferably 2 to 6 carbon atoms. Preferably, the compound is carnosine.
Hipkiss Alan R.
Michaelis Jurgen
Panagiotopoulos Sianna
King's College London
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Peptech Limited
Peptide Technology Limited
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