A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/159, 167/179
A61K 31/00 (2006.01) A61D 7/00 (2006.01) A61K 9/66 (2006.01)
Patent
CA 1089363
ABSTRACT OF THE DISCLOSURE A process is described for the introduction of health and/or welfare modifying agents, such as vaccines, to water-living animals such as fish. The health and/or welfare modifying agents are introduced into and across an epithelial membrane, such as the gill membrane, of the water-living animal by contacting the epithelial membrane with a hyperosmotic concentration of a membrane permeability altering agent, either simultaneously with or prior to contacting the animal with the health and/or welfare modifying agent. The membrane permeability altering agent renders the epithelial membrane reversibly permeable to the health and/or welfare modifying agent. Effective membrane permeability altering agents include chemical compounds having a molecular weight of about 58 to about 61, with the most preferred membrane permeability altering agents being selected from the group consisting of acetamide, urea, sodium chloride and mixtures thereof.
268168
Herschler Robert J.
Macrae & Co.
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