Method for therapeutically treating a clinically recognized...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/14 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 35/34 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2441289

The present invention provides therapeutic methods which employ one or more identifiable types of mammalian stem cells, and/or their progenitor progeny cells, and/or their lineage-committed descendant cells, and/or their partially- differentiated offspring cells - with or without completely differentiated cells to treat living mammalian subjects afflicted with a clinically recognized form of cardiopathology. The identifiable cell types include embryonic stem cells and their offspring cells; as well as the presently identified types of adult stem cells and their various offspring cells; and also include recently identified alternative cells types which have functional stem cell properties. Among the clinical forms of cardiopathology which can be efficaciously treated using the present therapeutic methods are myocardial infarction, myocarditis, heart failure, and cardiac dysrhythmia.

La présente invention concerne des méthodes thérapeutiques faisant appel à un ou plusieurs type(s) identifiable(s) de cellules souches mammaliennes et/ou de cellules progénitrices qui en sont issues, et/ou de cellules issues de leurs lignées, et/ou de cellules partiellement différenciées issues desdites cellules souches avec ou sans cellules totalement différenciées dans le but de traiter des mammifères souffrant d'une forme de cardiopathie cliniquement identifiée. Les types de cellules identifiables comprennent des cellules souches embryonnaires et les cellules qui en sont issues, les types de cellules souches adultes actuellement identifiés et les différentes cellules qui en sont issues, ainsi que des types de cellules alternatives identifiés récemment et présentant des propriétés fonctionnelles de cellules souches. Parmi les formes cliniques de cardiopathies qui peuvent être traitées efficacement au moyen des méthodes thérapeutiques selon la présente invention figurent l'infarctus du myocarde, la myocardite, l'insuffisance cardiaque et la dysrythmie cardiaque.

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