A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 39/12 (2006.01)
Patent
CA 2264924
A method for tolerizing a mammalian subject to administration of a live virus carrying a gene for delivery to a cell of the subject is disclosed. The method entails administering to the subject a suitable amount of an inactivated virus prior to administration of the live virus. The prior administration of the inactivated virus suppresses anti-virus cytotoxic T cells, permitting longer transgene persistence once the live virus is administered, and permitting effective readministration of live virus.
L'invention concerne un procédé pour rendre un sujet mammifère tolérant à l'administration d'un virus actif portant un gène destiné à une cellule dudit sujet. Ce procédé implique d'administrer au sujet une quantité appropriée d'un virus inactivé avant de lui administrer le virus actif. Cette administration préalable du virus inactivé supprime les cellules T cytotoxiques antivirales, ce qui permet une persistance transgène plus longue une fois que le virus est administré et rend plus efficace une réadministration du virus actif.
Chen Youhai
Wilson James M.
Gowling Lafleur Henderson Llp
The Trustees Of The University Of Pennsylvania
LandOfFree
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