C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/071 (2010.01) C12N 5/0775 (2010.01) A61K 31/455 (2006.01) A61K 35/14 (2006.01) A61K 38/18 (2006.01) A61K 38/26 (2006.01) C07K 14/575 (2006.01)
Patent
CA 2520861
The subject invention relates to a method of transdifferentiating mammalian non-pancreatic stem cells, such as mesenchymal stem cells (MSCs), to enter the pancreatic differentiations pathway. The MSCs are cultured under conditions that permit the expression of pancreatic differentiation markers, and these conditions include use of: (a) culture conditions that promote cell clustering; and/or (b) medium comprising glucagon-like peptide-1(GLP-1), hepatocyte growth factor (HGF) and/or nicotinamide.
L'invention concerne une méthode de transdifférentiation de cellules souches non pancréatiques mammaliennes, telles que des cellules souches mésenchymateuses (MSC), dans la voie de différentiation du pancréas. Ces cellules souches mésenchymateuses sont cultivées dans des conditions qui permettent d'exprimer des marqueurs de différentiation du pancréas, ces conditions comprenant : (a) l'utilisation de conditions de culture qui stimulent l'agglomération ; et/ou (b) l'utilisation d'un milieu comprenant le GLP-1 (glucagon-like peptide-1), le facteur de croissance des hépatocytes (HGF) et/ou de la nicotinamide.
Ixion Biotechnology Inc.
Sim & Mcburney
LandOfFree
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