Method for transferring genes to the heart using aav vectors

Details Method for transferring genes to the heart using aav vectors Method for transferring genes to the heart using aav vectors

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01) C12N 15/52 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2233167

The invention relates to the use of adeno-associated virus vectors for the transfer of genes to the heart and vasculature. The vector preferably contains a gene encoding a protein which improves heart and vascular function during heart failure. In a specific embodiment, the vector is introduced into the heart and vasculature via a catheter, with the aid of fluoroscopy. The method and vectors for use therein provide for safe and stable gene expression of the transferred genes.

Cette invention concerne l'utilisation de vecteurs de virus adéno-associés afin de transférer des gènes vers le coeur et l'appareil vasculaire. Le vecteur contient de préférence un gène codant une protéine qui permet d'améliorer le fonctionnement cardiaque et vasculaire lors d'une défaillance du coeur. Dans un mode de réalisation particulier, le vecteur est introduit dans le coeur et l'appareil vasculaire grâce à un cathéter et par fluoroscopie. Ce procédé et ces vecteurs assurent une expression génique sûre et stable des gènes transférés.

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