Method for transplanting lymphohematopoietic cells into mammal

Details Method for transplanting lymphohematopoietic cells into mammal Method for transplanting lymphohematopoietic cells into mammal

C - Chemistry, Metallurgy

07

K

C07K 14/505 (2006.01) A61K 48/00 (2006.01) C12N 15/62 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2530349

The present invention provides a method for transplanting lymphohematopoietic cells into a mammal, which comprises the step of injecting cells into a bone marrow cavity, and wherein the cells have an exogenous gene encoding a receptor that induces cell proliferation in response to ligand binding. By combining intra-bone marrow transplantation (iBMT) and selective amplifier gene (SAG), marrow conditioning before the injection of the cells can be omitted. The present invention further provides a bone marrow transplant and a kit for transplanting lymphohematopoietic cells into mammals. Furthermore, the invention provides an SAG particularly suitable for such transplantation.

L'invention concerne un procédé permettant de transplanter des cellules lymphohématopoiétiques chez un mammifère, qui consiste à injecter des cellules dans une cavité médullaire, les cellules ayant un gène exogène codant un récepteur qui induit la prolifération cellulaire en réponse à une liaison de ligand. La combinaison de la transplantation intramédullaire (iBMT) et du gène amplificateur sélectif (SAG), on peut omettre le conditionnement de la moelle avant l'injection des cellules. L'invention concerne en outre un transplant médullaire et une trousse conçue pour transplanter des cellules lymphohématopoiétiques chez des mammifères, ainsi qu'un gène amplificateur sélectif approprié pour une telle transplantation.

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