Method for treating abnormal cell growth

Details Method for treating abnormal cell growth Method for treating abnormal cell growth

A - Human Necessities

61

K

A61K 31/7068 (2006.01) A61K 31/4745 (2006.01) A61K 31/475 (2006.01) A61K 31/5377 (2006.01) A61K 31/7056 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2569277

The present Invention relates to a method of treating abnormal cell growth in a subject, comprising administering to said subject having abnormal cell growth: (a) a compound selected from the group consisting of a camptothecin, a camptothecin derivative, or a pharmaceutically acceptable salt, solvate or prodrug of said compounds; (b) a pyrimidine derivative or a pharmaceutically acceptable salt, solvate or prodrug of said pyrimidine derivative; and (c) an anti-tumor agent selected from the group consisting of antiproliferative agents, kinase inhibitors, angiogenesis inhibitors, growth factor inhibitors, cox-I inhibitors, cox~-II inhibitors, mitotic inhibitors, alkylating agents, anti-metabolites, intercalating antibiotics, growth factor inhibitors, radiation, cell cycle inhibitors, enzymes, topoisomerase inhibitors, biological response modifiers, antibodies, cytotoxics, anti-hormones, anti- androgens and combinations thereof.

Selon cette méthode de traitement de croissances cellulaires anormales chez un patient, on administre au patient souffrant de croissances cellulaires anormales: (a) un composé sélectionné dans le groupe constitué de camptothécine, de dérivés de camptothécine ou de sels, solvates ou prémédicaments pharmaceutiquement acceptables de ces composés; (b) un dérivé de pyrimidine ou un sel, solvate ou prémédicament pharmaceutiquement acceptable du dérivé de pyrimidine; et (c) un agent anticancéreux sélectionné dans le groupe constitué des agents antiprolifératifs, des inhibiteurs de kinase, des inhibiteurs de l'angiogénèse, des inhibiteurs du facteur de croissance, des inhibiteurs de cox-I, des inhibiteurs de cox-II, des inhibiteurs mitotiques, des agents alkylants, des anti-métabolites, des antibiotiques intercalants, des inhibiteurs du facteur de croissance, du rayonnement, des inhibiteurs du cycle cellulaire, des enzymes, des inhibiteurs de la topoisomérase, des modificateurs de la réponse biologique, des anticorps, des agents cytotoxiques, des anti-hormones, des anti-androgènes et leurs combinaisons.

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