Method for treating amyloidosis

Details Method for treating amyloidosis Method for treating amyloidosis

C - Chemistry, Metallurgy

07

C

C07C 309/01 (2006.01) A61K 31/00 (2006.01) A61K 31/185 (2006.01) A61K 31/216 (2006.01) A61K 31/255 (2006.01) A61K 31/357 (2006.01) A61K 31/39 (2006.01) A61K 31/4409 (2006.01) A61K 31/4436 (2006.01) A61K 31/7048 (2006.01) A61K 47/48 (2006.01) C07C 305/06 (2006.01) C07C 305/10 (2006.01) C07C 309/05 (2006.01) C07C 309/11 (2006.01) C07C 309/17 (2006.01) C07C 309/24 (2006.01) C07C 309/42 (2006.01) C07D 213/75 (2006.01) C07D 319/06 (2006.01) C07D 327/04 (2006.01) C07D 411/12 (2006.01) C07H 15/04 (2006.01) C07H 9/

Patent

CA 2213759

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier molecules include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

La présente invention concerne des composés et des procédés thérapeutiques permettant d'empêcher la formation de dépôts amyloïdes chez un sujet quelles qu'en soient les conditions cliniques. On empêche la formation de dépôts amyloïdes en administrant au sujet une quantité suffisante d'un composé comprenant un groupe anionique et une molécule porteuse, ou l'un de ses sels pharmaceutiquement acceptables, de façon à empêcher toute interaction entre une protéine amyloïdogène et un constituant de la membrane basale. Les groupes anioniques préférés sont les sulfonates et les sulfates. Parmi les molécules porteuses préférées on compte les glucides, des polymères, des peptides, des dérivés de peptides, des groupes aliphatiques, des groupes alicycliques, des groupes hétérocycliques, des groupes aromatiques et leurs combinaisons.

Affiliated with

Also associated with

Rating

Method for treating amyloidosis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating amyloidosis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating amyloidosis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1454700