Method for treating amyloidosis

Details Method for treating amyloidosis Method for treating amyloidosis

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 31/185 (2006.01) A61K 31/737 (2006.01) A61K 31/795 (2006.01) A61L 33/08 (2006.01) C07H 11/00 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2159326

Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates. Preferred carrier include carbohydrates, polymers, peptides, peptide derivatives, aliphatic groups, alicyclic groups, heterocyclic groups, aromatic groups and combinations thereof.

Des composés et procédés thérapeutiques permettent d'inhiber un dépôt amyloïde chez un sujet, quel que soit son site clinique. Cette inhibition intervient après administration à ce sujet d'une quantité efficace d'un composé thérapeutique comprenant un groupe anionique, ou un de ses sels pharmaceutiquement acceptables, et une molécule porteuse, de façon à inhiber une interaction survenant entre une protéine amylogène et un constituant d'une membrane basale. Les groupes anioniques préférés sont des sulfonates et des sulfates. Les molécules porteuses préférées incluent des hydrates de carbone, des polymères, des peptides, des dérivés peptidiques, des groupes aliphatiques, des groupes alicycliques, des groupes hétérocycliques, des groupes aromatiques et leurs combinaisons.

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