Method for treating and inhibiting gastric and duodenal ulcers

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2183329

A method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of the following formula (I): (NeuAc-.alpha.(2-3)-pGal- .beta.(1)-(-X-)m-(-Y-)n-)p-Z wherein X is a chemical bond or a group capable of linking the p galactose to either the linking group Y or the multivalent support Z; wherein the C1 glycosidic oxygen of galactose may be replaced by N, S or C; Y is a linking group; Z is a multivalent support; m is 0 or 1; n is 0 or 1; and p is an integer of 2-1,000 is described. Also described is a method for treating and/or inhibiting gastric and duodenal ulcers, comprising administering a pharmaceutical composition comprising an oligosaccharide of the formula (II): NeuAc-.alpha.(2-3)-pGal-.beta.(1)-A wherein A is a group capable of bonding to the p galactose; wherein the C1 glycosidic oxygen of galactose may be replaced by N, S or C.

La présente invention concerne un procédé traitant et/ou inhibant les ulcères gastriques ou duodénaux par administration d'une composition pharmaceutique comprenant un oligosaccharide de la formule (I): NeuAc-.alpha.(2-3)-pGal-.beta.(1)-(-X-)¿m?-(-Y-)¿n?-)¿p?-Z. Dans cette formule générale (I), X représente une liaison chimique ou un groupe pouvant lier le p galactose soit au groupe de liaison Y, soit au support multivalent Z; où l'oxygène glycosidique C¿1? du galactose est remplaçable par N, S ou C; Y représente un groupe de liaison; Z représente un support multivalent; m est un entier valant 0 ou 1; n est un entier valant 0 ou 1; et p est un entier valant de 2 à 1000. L'invention concerne en outre un procédé traitant et/ou inhibant les ulcères gastriques et duodénaux par administration d'une composition pharmaceutique comprenant un oligosaccharide, de la formule (II): NeuAc-.alpha.(2-3)-pGal-.beta.(1)-A. Dans cette formule (II), A représente un groupe pouvant se lier au p galactose; l'oxygène glycosidique C¿1? du galactose étant remplaçable par N, S ou C.

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