A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/192 (2006.01) A61K 31/216 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/385 (2006.01)
Patent
CA 2535260
The present invention relates to a method of treatment of cachexia in a subject in need of treatment. More specifically, the present invention relates to the use of retinoid compounds that act on retinoid X receptors (RXRs) for the treatment of cachexia in a subject in need of treatment. The cachexia is associated with, in other words a complication of, a primary disease, condition or disorder. Primary diseases, conditions and disorders include, but are not limited to, cancer, AIDS, liver cirrhosis, diabetes mellitus, chronic renal failure, chronic obstructive pulmonary disease, chronic cardiac failure, immune system diseases (e.g., rheumatoid arthritis and systemic lupus erythematosus), tuberculosis, cystic fibrosis, gastrointestinal disorders (e.g., irritable bowel syndrome and inflammatory bowel disease), Parkinson's disease, anorexia nervosa, dementia, major depression, an aged condition and sarcopenia.
L'invention concerne un procédé de traitement de la cachexie chez un sujet nécessitant un traitement. L'invention concerne plus particulièrement l'utilisation de composés rétinoïdes agissant sur des récepteurs X de rétinoïdes (RXR) pour le traitement de la cachexie chez un sujet nécessitant un traitement. La cachexie est associée, c.-à-d. qu'elle est une complication, d'une maladie ou d'un trouble primaire. Les maladies ou troubles primaires peuvent inclure le cancer, le SIDA, la cirrhose du foie, le diabète sucré, l'insuffisance rénale chronique, la bronchopneumopathie chronique obstructive, l'insuffisance cardiaque chronique, des maladies du système immunitaire (par ex. l'arthrite rhumatoïde et le lupus érythémateux systémique), la tuberculose, la fibrose cystique, des troubles gastro-intestinaux (par ex. le syndrome du côlon irritable et le syndrome d'inflammation du côlon), la maladie de Parkinson, la névrose anorexique, la démence, la dépression majeure, les troubles de la vieillesse et la sarcopénie.
Chandraratna Roshantha A.
Jiang Guang Liang
Yuan Yang-Dar
Allergan Inc.
Gowling Lafleur Henderson Llp
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