Method for treating cells resistant to antineoplastic agents

Details Method for treating cells resistant to antineoplastic agents Method for treating cells resistant to antineoplastic agents

A - Human Necessities

61

K

A61K 31/366 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2401104

The present invention relates to methods for treating multidrug resistant cells, preferably multidrug resistant cancer cells with discodermolide. Discodermolide is found to be effective in limiting the growth of otherwise growth unregulated cells having tubulin mutations and in promoting phosphorylation of the oncogene RAF-1.

L'invention concerne des procédés de traitement pour cellules multirésistantes, de préférence les cellules cancéreuses mulltirésistantes à discodermolide, lequel limite efficacement la croissance de cellules normalement non régulées en croissance présentant des mutations de tubuline et favorise la phosphorylation de l'oncogène RAF-1.

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