Method for treating cytokine mediated hepatic injury

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01)

Patent

CA 2326065

A method of modulating cytokine mediated hepatic injury by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, deltorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration in the range of about 0.5 mg/kg to about 20 mg/kg in a physiologically acceptable formulation blocks a cytokine cascade in a murine model of septic shock. A therapeutic method of modulating cytokine mediated acute inflammatory, trauma induced and toxin induced hepatic injury, particularly via tumor necrosis factor modulation, is thus disclosed.

Il est possible, dans le cadre de cette invention, de moduler une maladie hépatique liée à la cytokine en administrant des deltorphines à un mammifère. Il est possible d'administrer la deltorphine I SEQ ID N· 1, la deltorphine II SEQ ID N· 2 ou leur combinaison. L'administration d'une formulation, acceptable du point de vue physiologique, dont la teneur en deltorphine est comprise entre 0,5 et 20 mg/kg, a pour effet de bloquer une cascade de cytokine chez un modèle murin de choc septique. Cette invention concerne également une méthode thérapeutique de modulation d'une maladie hépatique, inflammatoire aiguë, liée à la cytokine, provoquée par un trauma ou déclenchée par une toxine, notamment par le biais de la modulation du facteur de nécrose des tumeurs.

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