Method for treating elevated intraocular pressure, including...

A - Human Necessities – 61 – K

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A61K 38/46 (2006.01) A61K 9/00 (2006.01) A61K 38/47 (2006.01)

Patent

CA 2515022

Hyaluronic acid, a polymer found in the trabecular meshwork of the eye, has a polymeric structure that is broken down by the enzyme hyaluronidase. A method is provided for reducing elevated intraocular pressure in an eye of a patient, such as a patient suffering from glaucoma, by administering modified hyaluronidase to the surface of the eye as a drop, spray, ointment, sustained- release or non-sustained release unit, and allowing the hyaluronidase to remain within the anterior chamber of the eye. The hyaluronidase is modified to enhance penetration through the corneal barrier, and is administered in an amount effective to reduce an elevated intraocular pressure. The method thus reduces the elevated intraocular pressure in the eye of a glaucoma patient without undesirable side effects.

L'acide hyaluronique, polymère trouvé dans le tissu trabéculaire de l'oeil, présente une structure polymère qui est dégradée par l'enzyme hyaluronidase. L'invention concerne un procédé permettant de réduire la pression intra-oculaire élevée de l'oeil d'un patient, tel qu'un patient souffrant d'un glaucome, par administration de hyaluronidase modifiée, à la surface de l'oeil, sous forme de gouttes, pulvérisation, pommade, en unités à libération prolongée ou non, et tout en laissant agir la hyaluronidase dans la chambre antérieure de l'oeil. La hyaluronidase est modifiée pour accroître la pénétration à travers la barrière cornéenne, et est administrée en une quantité efficace pour réduire une pression intra-oculaire élevée. Le procédé selon l'invention permet ainsi de réduire la pression intra-oculaire élevée dans l'oeil d'un patient souffrant d'un glaucome, sans effets secondaires indésirables.

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