Method for treating inflammation

Details Method for treating inflammation Method for treating inflammation

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 39/395 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2395406

A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.

L'invention concerne une méthode destinée à traiter l'inflammation associée à l'IL-20. Cette méthode consiste à administrer un antagoniste de l'IL-20 pour traiter l'inflammation et les maladies associées. L'antagoniste peut être un anticorps se fixant à l'IL-20 ou son récepteur ou un récepteur soluble se fixant à l'IL-20. Lesdites maladies peuvent être, par exemple, une maladie respiratoire de l'adulte, le psoriasis, l'eczéma, la dermatite de contact, la dermatite atopique, le choc septique, une insuffisance organique multiple, une lésion pulmonaire inflammatoire, la pneumonie bactérienne, une maladie intestinale inflammatoire, la polyarthrite rhumatoïde, l'asthme, la rectocolite hémorragique et la maladie de Crohn.

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