Method for treating ischemic tissue

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2235372

The present invention provides a method for treating ischemic tissue in a mammal which comprises injecting said tissue with an effective amount of a nucleic acid capable of expressing an angiogenic protein. The method of the present invention may be used to treat any ischemic tissue, i.e., a tissue having a deficiency in blood as the result of an ischemic disease. Such tissues can include, for example, muscle, brain, kidney and lung. Ischemic diseases include, for example, cerebrovascular ischemia, renal ischemia, pulmonary ischemia, limb ischemia, ischemic cardiomyopathy and myocardial ischemia.

La présente invention se rapporte à un procédé de traitement des tissus ischémiés d'un mammifère, ce procédé consistant à injecter dans ces tissus une quantité efficace d'un acide nucléique capable d'exprimer une protéine angiogénique. Ce procédé peut être utilisé pour traiter tout tissu ischémié, c'est-à-dire un tissu présentant une déficience sanguine résultant d'une maladie ischémique. Ces tissus peuvent être, par exemple, ceux des muscles, du cerveau, des reins et des poumons. Les maladies ischémiques sont, par exemple, l'ischémie cérébro-vasculaire, l'ischémie rénale, l'ischémie pulmonaire, l'ischémie des membres, la myocardiopathie ischémique et l'ischémie myocardique.

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