Method for treating macrophage pathogen infections

Details Method for treating macrophage pathogen infections Method for treating macrophage pathogen infections

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/18 (2006.01) A61K 38/55 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2130995

There is disclosed a method of treating an individual infected with a macrophage pathogen comprising administering an effective amount of a TGF-.beta. antagonist, Macrophage pathogens include any pathogenic microorganism that replicates within macrophage cell hosts as their exclusive or primary host cells. TGF-.beta. antagonists include blocking antibodies specific for a human TGF-.beta., soluble TGF-.beta. receptors, protease inhibitors that inactivate a protease responsible for activating a precursor TGF-.beta. into an active, mature TGF-.beta., and combinations thereof.

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