Method for treating nervous system disorders and conditions

Details Method for treating nervous system disorders and conditions Method for treating nervous system disorders and conditions

A - Human Necessities

61

K

A61K 31/403 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2574315

The present invention is directed to selective dopamine reuptake inhibitors, including (-)-1-(3,4-dichlorophenyl)-3-azabicyclo~3.1.0!hexane, (-)-1- (4~methylphenyl)-3-azabicyclo~3.1.0!hexane, mazindol, methylphenidate, and 1- ~2-~bis(4-fluorophenyl)methoxy!ethyl!-4-(3-phenylpropyl) piperazine, and methods of their use for treating nervous system disorders and conditions selected from vasomotor symptoms (VMS), chronic pain, and Shy Drager syndrome.

La présente invention concerne des inhibiteurs du recaptage de la dopamine sélectifs comprenant (-)-1-(3,4-dichlorophényle)-3-azabicyclo[3.1.0]hexane, (-)-1-(4-méthylphényle)-3-azabicyclo[3.1.0]hexane, mazindol, méthylphénidate, et 1-[2-[bis(4-fluorophényle)méthoxy]éthyle]-4-(3-phénylpropyle) piperazine, et des procédés d'utilisation de ces composés pour traiter certaines pathologies et certains troubles du système nerveux, notamment, des symptômes vasomoteurs (VMS), la douleur chronique et le syndrome Shy Drager.

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