A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/708 (2006.01) A61K 31/7084 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2465894
The present invention provides a method of preventing or treating aninflammatory disease, including but not limited to, sinusitis, rhinitis, conjunctivitis,asthma, dermatitis, inflammatory bowel disease, inflammatory collagen vasculardiseases, glomerulonephritis, inflammatory skin diseases, and sarcoidosis. The method comprises administrating to a subject a pharmaceutical formulation comprising a nucleotide receptor agonist, such as nucleoside diphosphate, nucleoside triphosphate, or dinucleoside polyphosphate, according to general formula Ia, IBC, IIa, Ii, or III. Preferred in dications of the present invention are perennial allergic rhinitis, seasonal allergic rhinitis, infectious allergic rhinitis, and allergic conjunctivitis.
La présente invention concerne une méthode de prévention ou de traitement d'une maladie inflammatoire, notamment, mais non exclusivement, la sinusite, la rhinite, la conjonctivite, l'asthme, la dermite, la maladie inflammatoire de l'intestin, les collagénoses avec manifestations vasculaire inflammatoires, la glomérulonephrite, les maladies inflammatoires de la peau et la sarcoidose. La méthode consiste à administrer à un patient une formulation pharmaceutique contenant un agoniste des récepteurs des nucléotides, notamment un diphosphate de nucléoside, un triphosphate de nucléoside ou un polyphosphate de dinulcéoside selon la formule générale Ia, IBC, IIa, Ii, ou III. De préférence, les indications de cette invention sont la rhinite allergique apériodique, le rhume des foins, la rhinite allergique infectieuse et la conjonctivite allergique.
Peterson Ward M.
Yerxa Benjamin R.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
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