Method for treating prostate diseases based on local...

A - Human Necessities – 61 – K

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A61K 47/02 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/167 (2006.01) A61K 31/277 (2006.01) A61K 38/22 (2006.01) A61K 45/06 (2006.01) A61P 13/08 (2006.01)

Patent

CA 2602776

A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs, and ii) administering locally into the prostate a controlled release pharmaceutical composition comprising one or more active substances in a biodegradable ceramic carrier. The biodegradable hydrating ceramic may be selected from the group consisting of non-hydrated or hydrated calcium sulphate, calcium phosphate, calcium carbonate, calcium fluoride, calcium silicate, magnesium sulphate, magnesium phosphate, magnesium carbonate, magnesium fluoride, magnesium silicate, barium sulphate, barium phosphate, barium carbonate, barium fluoride, barium silicate, or mixtures thereof. In a specific embodiment, the biodegradable hydrating ceramic is non- hydrated or hydrated calcium sulphate.

L'invention concerne une méthode de traitement de maladies prostatiques chez un sujet. La méthode consiste à: i) administrer facultativement au sujet un complément de dose initiale d'une ou de plusieurs substances actives et/ou de promédicaments; et ii) administrer localement dans la prostate une composition pharmaceutique à libération lente contenant une ou plusieurs substances actives placées dans un support céramique biodégradable. La céramique hydratante biodégradable peut être sélectionnée dans le groupe constitué par un sulfate de calcium non hydraté ou hydraté, un phosphate de calcium, un carbonate de calcium, un fluorure de calcium, un silicate de calcium, un sulfate de magnésium, un phosphate de magnésium, un carbonate de magnésium, un fluorure de magnésium, un silicate de magnésium, un sulfate de baryum, un phosphate de baryum, un carbonate de baryum, un fluorure de baryum, un silicate de baryum, ou leurs mélanges. Dans un mode de réalisation spécifique, la céramique hydratante biodégradable est un sulfate de calcium non hydraté ou hydraté.

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