A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/728 (2006.01)
Patent
CA 2616230
The present invention is directed to methods of treating sickle cell disease and its sequeale, including vaso-occlusive crisis. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of a polyanionic polysaccharide, such as pentosan polysulfate, sulodexide, or its pharmaceutically acceptable salts thereof. The methods of the present invention are useful in reducing the incidence, severity, or duration of SCD and its sequelae. The compound of the present method can also be used in conjunction with other therapeutic agents useful to treat sickle cell disease thus enhancing the therapeutic effect or reducing the required doses to treat sickle cell disease.
La présente invention concerne des méthodes destinées à traiter la drépanocytose et ses séquelles, y compris la crise vaso-occlusive. Cette méthode consiste à administrer, à un sujet le nécessitant, une composition pharmaceutique comprenant une dose efficace d'un polysaccharide polyanionique, tel que le polysulfate de pentosane ou le sulodexide, ou des sels pharmaceutiquement acceptables correspondants. Les méthodes de la présente invention sont utiles pour réduire l'incidence, la gravité ou la durée de la drépanocytose et de ses séquelles. Le composé de la présente méthode peut également être utilisé conjointement avec d'autres agents thérapeutiques utiles pour traiter la drépanocytose en vue d'un renforcement de l'effet thérapeutique ou d'une réduction des doses requises pour traiter la drépanocytose.
Engleman Edgar G.
Yu Chen M.
Smart & Biggar
Trf Pharma Inc.
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