A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/47 (2006.01) A61K 36/38 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2650022
The present invention provides methods for treating constipation-predominant irritable bowel syndrome comprising administering to a patient in need thereof, a polymeric proanthocyanidin composition from a Croton species or Calophyllum species in an amount sufficient to treat constipation-predominant irritable bowel syndrome (c-IBS). Treatment of c-IBS includes the treatment of the constipation component of c-IBS as well as the pain and abdominal discomfort associated with c-IBS. In one embodiment, the polymeric proanthocyanidin compound is crofelemer. The present invention in an alternative embodiment also provides methods for treating alternating constipation-predominant/diarrhea-predominant irritable bowel syndrome.
L'invention concerne des méthodes de traitement du syndrome du côlon irritable à constipation prédominante, qui consistent à administrer à un patient nécessitant un tel traitement une composition de proanthocyanidine polymère isolée à partir d'une espèce Croton ou d'une espèce Calophyllum à une dose suffisante pour traiter le syndrome du côlon irritable à constipation prédominante (c-IBS). Le traitement du c-IBS consiste à traiter la constipation associée au c-IBS ainsi que la douleur et la gêne abdominale associées au c-IBS. Dans un mode de réalisation, le composé proanthocyanidine polymère est du crofelemer. Dans un autre mode de réalisation, l'invention concerne des méthodes de traitement du syndrome du côlon irritable à alternance de constipation prédominante et de diarrhée prédominante.
Quart Barry
Rosenbaum David
Gowling Lafleur Henderson Llp
Napo Pharmaceuticals Inc.
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