Method for treatment of depression and depressive mood...

A - Human Necessities – 61 – K

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A61K 31/475 (2006.01) A61K 9/06 (2006.01) A61K 31/522 (2006.01) A61K 36/24 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2591315

A method for treatment of depression and depressive mood disorders. The patient is administered an amount of a compound that increases the catalytic activity of MAO-A, so as to increase synaptic metabolism of serotonin to 5-HIAL. The effective compound is preferably reserpine, administered in a dosage of less than about 0.03mg per day. The reserpine may be administered transdermally at a dosage in the range from about 0.002mg per day to about 0.02mg per day. A caffeine compound may be administered simultaneously so as to compensate for an antihypertensive effect of the reserpine. The caffeine compound may be combined with the reserpine in a transdermal cream.

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