Method for treatment of dermatological disorders

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 69/90 (2006.01) A61K 31/215 (2006.01) A61K 31/225 (2006.01) A61K 31/23 (2006.01) A61K 31/235 (2006.01) A61K 31/60 (2006.01) A61K 31/616 (2006.01) A61K 31/621 (2006.01) C07C 69/34 (2006.01) C07C 69/353 (2006.01) C07C 69/48 (2006.01) C07C 235/60 (2006.01) C07C 403/12 (2006.01)

Patent

CA 2275867

A compound effect for the treatment of dermatological disorders comprises a mono- or diester of an .alpha., .omega.-dicarboxylic acid, wherein the alcohol moiety of the said ester comprises a keratolytically active alcohol. The compound may have formula (I), where n is in the range of 6 and 12; m is in the range of 0 and 8; R' is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl, OH, NHR'', CONHR'' and COOR''; R'' is selected from the group consisting of H, alkyl, aryl, alkenyl, and benzyl; and Y is selected from the group consisting of H, alkyl, aryl, alkenyl, benzyl and X.

L'invention concerne un composé efficace pour traiter des troubles dermatologiques, comportant un mono- ou diester d'un acide .alpha., .omega.-dicarboxylique, le fragment alcool dudit ester comprenant un alcool à action kératolytique. Ce composé peut avoir la formule (I) dans laquelle n se situe dans la plage comprise entre 6 et 12; m se situe dans la plage comprise entre 0 et 8; R' est choisi dans le groupe composé de H, alkyle, aryle, alcényle, benzyle, OH, NHR'', CONHR'' et COOR''; R'' est choisi dans le groupe composé de H, alkyle, aryle, alcényle, et benzyle; et Y est choisi dans le groupe composé de H, alkyle, aryle, alcényle, benzyle and X.

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