C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2339413
A method for treating metastatic tumor cells of a subject is disclosed. The method comprises administrating to the subject an antisense molecule comprising a nucleotide sequence which is complementary to an RNA sequence of a protease activated receptor (PAR) protein, or an antibody molecule capable of binding to a PAR protein. A method is also described for the treatment of disorders involving the implantation of a placenta in a female subject comprising administrating to the subject the antisense molecule. Also disclosed is the antisense molecule and a pharmaceutical composition comprising it.
La présente invention concerne un traitement des cellules métastatiques. Ce traitement consiste en l'administration au patient d'une molécule antisens comprenant une séquence nucléotidique complémentaire d'une séquence d'ARN d'une protéine de récepteur activé par protéase ou "PAR" (protease activated receptor) ou une molécule anticorps capable de se lier à une protéine PAR. L'invention concerne également un traitement de troubles impliquant l'implantation d'un placenta chez une patiente, lequel traitement consiste en l'administration à cette patiente d'une molécule antisens. L'invention concerne enfin la molécule antisens considérée ainsi qu'une composition pharmaceutique à base de cette molécule.
Hadasit Medical Research Services & Development Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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