Method for treatment with bucindolol based on genetic targeting

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2581086

The present invention concerns the use of methods for evaluating bucindolol treatment for a patient, particularly one with heart failure. It concerns methods for determining whether to administer or prescribe bucindolol to a patient based on whether the patient is homozygous for the Arg 389 polymorphism in the .beta.1-adrenergic receptor (AR).

L'invention concerne l'utilisation de procédés d'évaluation d'un traitement faisant intervenir du bucindolol pour un patient, en particulier un patient souffrant d'insuffisance cardiaque. L'invention concerne des procédés permettant de déterminer s'il convient d'administrer ou de prescrire du bucindolol à un patient si ce dernier est homozygote pour le polymorphisme Arg 389 dans le récepteur ß1-adrénergique (AR).

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