A - Human Necessities – 23 – L
Patent
A - Human Necessities
23
L
A23L 1/308 (2006.01) A23L 1/0522 (2006.01) A61K 31/724 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2547934
Disclosed are methods of producing a blunted postprandial glycemic response in an individual, and/or reducing postprandial insulin secretion, said methods comprising administering to the individual a nutritional or other product comprising gamma-cyclodextrin. Also disclosed are similar other methods directed toward the use of such products to provide weight and appetite control, to normalize blood glucose levels in individuals with impaired glucose tolerance, to minimize nighttime hypoglycemia in diabetic and non- diabetic patients, to prevent reactive hypoglycemia in susceptible non- diabetics, to normalize blood glucose levels in individuals with gestational diabetes or impaired glucose tolerance during gestation, and/or to provide a prolonged glycemic response during exercise. The methods are based upon the discovery that gamma-cyclodextrins are rapidly metabolized and absorbed in the small intestine, but subsequently result in a surprisingly blunted postprandial glycemic response and reduced insulin secretion.
L'invention concerne des méthodes visant à générer une réponse glycémique postprandiale fermée chez un individu, et/ou à réduire la sécrétion de l'insuline postprandiale, lesdites méthodes consistant à administrer à l'individu un produit nutritif ou autre produit à base de gamma-cyclodextrine. L'invention concerne d'autres méthodes semblables consistant à utiliser lesdits produits dans la régulation du poids et de l'appétit, la normalisation des niveaux de glycémie chez les individus présentant une intolérance au glucose, la réduction de l'hypoglycémie nocturne chez les patients diabétiques et non diabétiques, la prévention de l'hypoglycémie réactive chez les non diabétiques, la normalisation des niveaux de glycémie chez les individus souffrant de diabète gestationnel ou d'intolérance au glucose au cours de la gestation, et/ou l'obtention d'une réponse glycémique prolongée au cours d'un exercice physique.
Chow Jomay
Lai Chron-Si
Wolf Bryan
Abbott Laboratories
Mbm Intellectual Property Law Llp
LandOfFree
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