Method for visualizing the base sequence of nucleic acid...

Details Method for visualizing the base sequence of nucleic acid... Method for visualizing the base sequence of nucleic acid...

C - Chemistry, Metallurgy

12

Q

150/8.5

C12Q 1/68 (2006.01)

Patent

CA 2021002

ABSTRACT OF THE DISCLOSURE A method for determining and visualizing the base sequence of nucleic acid polymers, especially DNA and RNA, with a scanning probe microscope having a tip, the method including replacing the oxygen in the nucleic acid polymer with sulfur, complexing the sulfur with a metal such as mercury, and passing the tip over the complexed polymer in a scanning path to measure the potential and record the difference in electrical conductivity at preselected increments along the scanning path.

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