Method of activating a novel ligand regulatory pathway

Details Method of activating a novel ligand regulatory pathway Method of activating a novel ligand regulatory pathway

A - Human Necessities

61

K

A61K 38/17 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2234090

A novel ligand regulatory pathway is disclosed and methods of activating the novel pathway in a cell expressing a ligand for an Eph subfamily receptor tyrosine kinase protein. Methods are provided for identifying substances capable of activating the ligand regulatory pathway. Therapeutic methods for affecting neuronal development and regeneration and pharmaceutical compositions using the substances and Eph subfamily receptor tyrosine kinase proteins are also described.

L'invention porte sur une nouvelle voie de régulation de ligand ainsi que sur des procédés d'activation de cette nouvelle voie dans une cellule exprimant un ligand pour une protéine tyrosine kinase réceptrice de la sous-famille Eph. Elle concerne également des procédés permettant d'identifier des substances capables d'activer la voie de régulation du ligand. Elle a, en outre, trait à des techniques thérapeutiques visant à influer sur le développement et la régénération des neurones, ainsi qu'à des compositions pharmaceutiques utilisant ces substances et des protéines tyrosine kinase réceptrices de la sous-famille Eph.

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