Method of activating dendritic cells

Details Method of activating dendritic cells Method of activating dendritic cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 31/00 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2259140

Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present tumor, viral or bacterial antigens to T cells, and can be useful in vaccination protocols. Other cytokines can be used in separate, sequential or simultaneous combination with the activated, antigen-pulsed dendritic cells. Also disclosed are methods for stimulating an immune response using the antigen-expressing, activated dendritic cells.

On décrit des cellules dendritiques activées et exprimant un antigène. De telles cellules sont utiles pour présenter des antigènes bactériens, viraux ou tumoraux aux lymphocytes T, et elles peuvent servir également dans des protocoles de vaccination. On peut aussi employer d'autres cytokines, en combinaison simultanée, séquentielle ou séparée, avec ces cellules dendritiques activées exprimant un antigène spécifique. On décrit également des procédés de stimulation d'une réponse immune au moyen de cellules dendritiques activées et exprimant un antigène.

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